Me Talk Pretty One Day is a funny collection of essays in which Sedaris writes about a variety of true life experiences.
He devotes space to his Greek-American family (especially his father), employers, tourists, nudists, speech therapists, and himself. The best essays in the book are the pieces that focus on France and the author's attempts to learn to speak French.
Having also recently read Barrel Fever, I would say Me Talk Pretty One Day is definitely the better of the two books and that Sedaris is clearly at his best writing non-fiction, where his cranky humor really shines. From what I've heard, these essays are even funnier when heard aloud, with the delivery raising them up a notch.